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Anti-hypertensive effect of gamma-amino butyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study.

Shimada M, Hasegawa T, Nishimura C, Kan H, Kanno T, Nakamura T, Matsubayashi T. Clin Exp Hypertens. 2009 Jun;31(4):342-54.

Key Finding: “These results suggest that GABA-rich Chlorella significantly decreased high-normal blood pressure and borderline hypertension, and is a beneficial dietary supplement for prevention of the development of hypertension.”

Nutritional supplementation with Chlorella pyrenoidosa for mild to moderate hypertension.

Merchant RE, Andre CA, Sica DA. J Med Food. 2002 Fall;5(3):141-52.

Key Finding: “The results indicate that, for some subjects with mild to moderate hypertension, a daily dietary supplement of Chlorella reduced or kept stable their sitting diastolic blood pressure.”

A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis.

Merchant RE, Andre CA. Alter Ther Health Med. 2001 May-Jun;7(3):79-91.

Key Finding: “The potential of chlorella to relieve symptoms, improve quality of life, and normalize body functions in patients with fibromyalgia, hypertension, or ulcerative colitis suggests that larger, more comprehensive clinical trials of chlorella are warranted.”

Identification of antihypertensive peptides from peptic digests of two microalgae, Chlorella vulgaris and Spirulina platensis.

Suetsuna K, Chen JR. Mar Biotechnol. 2001 Jul;3(4):305-9.

Key Finding: “The peptidic fractions that inhibited angiotensin I-converting enzyme (ACE) were separated from the peptic digests of 2 microalgae, Chlorella vulgaris and Spirulina platensis, by ion exchange chromatography and gel filtration. Oral administration of peptidic fractions into spontaneously hypertensive rats at 200 mg/kg of body weight resulted in marked antihypertensive effects.”

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