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Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet

Melnik B. Dermatoendocrino. 2012 Jan 1;4(1):20-32.

Key Finding: Dietary intervention in acne to attenuate mTORC1 signaling means reducing consumption of leucine-rich meat and dairy proteins.

Evidence for acne-promoting effects of milk and other insulinotropic dairy products.

Melnik BC. Nestle Nutr Workshop Ser Pediatr Program. 2011;67:131-45.

Key Finding: “Restriction of milk consumption will have an enormous impact on the prevention of epidemic western diseases like obesity, diabetes mellitus, cancer, neurodegenerative diseases and acne.”

Acne, dairy and cancer: The Salpha-P link.

Danby FW. Dermatoendocrinol. 2009 Jan;1(1):12-6.

Key Finding: “A potent link to dairy seems to exist for three hormone-responsive glands. Acne, breast cancer and prostate cancer have all been linked epidemiologically to dairy intake. Although mechanisms postulated here remain to be accurately defined, the likely link involves Insulin-like Growth Factor-1 as a general stimulant, synergized by the steroid hormones present in milk. The IGF-1 may be either absorbed from milk, or stimulate by its ingestion, or both. The Salpha-reduced compound Salpha-pregnanedione (Salpha-P) present in milk is a direct precursor of dihydrotestosterone and may act through that pathway in prostate cancer, but Salpha-P has also recently been shown to be capable of inducing estrogen receptors in breast cancer cells, upregulating cancer cells’ sensitivity to estrogen.”

High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study.

Ismail NH, et al. BMC Dermatol. 2012 Aug 16;12:13.

Key Finding: “A case control study was conducted among 44 acne vulgaris patients and 44 controls aged 18 to 30 years. The frequency of milk and ice cream consumptions was significantly higher in cases compared to control. Milk and ice cream were positively associated with acne vulgaris.”

 

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